Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives
The functional integration of external and internal signals forms the basis of information
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …
Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state
T Fuchs, SJ Jefferson, A Hooper, PHP Yee… - Molecular …, 2017 - nature.com
Major depressive disorder (MDD) is associated with reduced concentrations of γ-
aminobutyric acid (GABA) that are normalized by antidepressant therapies. Moreover …
aminobutyric acid (GABA) that are normalized by antidepressant therapies. Moreover …
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders
Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …
problem solving, occur in depressive episodes, often persist during remission, predict …
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Our knowledge of the pathophysiology of affect dysregulation has progressively increased,
but the pharmacological treatments remain inadequate. Here, we summarize the current …
but the pharmacological treatments remain inadequate. Here, we summarize the current …
[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
Evidence for GABAergic inhibitory deficits in major depressive disorder
Converging evidence suggests that deficits in gamma-aminobutyric acid (GABA) functioning
are implicated in the pathophysiology of major depressive disorder (MDD). This is …
are implicated in the pathophysiology of major depressive disorder (MDD). This is …
Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes
Abstract γ-aminobutyric acid (GABA) inhibitory interneurons play a key role in efferent and
afferent control of principle neuron activity in the prefrontal cortex (PFC), thereby regulating …
afferent control of principle neuron activity in the prefrontal cortex (PFC), thereby regulating …
Somatostatin, neuronal vulnerability and behavioral emotionality
Somatostatin (SST) deficits are common pathological features in depression and other
neurological disorders with mood disturbances, but little is known about the contribution of …
neurological disorders with mood disturbances, but little is known about the contribution of …
Behavioral deficits induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation
Introduction Deficits in somatostatin-positive gamma-aminobutyric acid interneurons (SST+
GABA cells) are commonly reported in human studies of mood and anxiety disorder patients …
GABA cells) are commonly reported in human studies of mood and anxiety disorder patients …
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses
MV Fogaça, M Wu, C Li, XY Li, MR Picciotto… - Molecular …, 2021 - nature.com
Major depressive disorder (MDD) is associated with alterations of GABAergic interneurons,
notably somatostatin (Sst) as well as parvalbumin (Pvalb), in cortical brain areas. In addition …
notably somatostatin (Sst) as well as parvalbumin (Pvalb), in cortical brain areas. In addition …