Theme issue: Psoriasis loci. Despite the complex correlation structure across the MHC due
to extensive linkage disequilibrium (Box 1)(16), HLA-C* 06: 02 is now confidently …

Psoriasis is a common skin disorder of multifactorial origin. Genomewide scans for disease
susceptibility have repeatedly demonstrated the existence of a major locus, PSORS1 …

Psoriasis, a common skin disorder, is widely regarded to be multifactorial in origin including
gene-gene and gene-environment interactions. Genetic and allelic heterogeneity …

During the past 5 years, genome‐wide association studies (GWAS), primarily based on
single nucleotide polymorphism markers, have identified many loci as potential psoriasis …

Previous studies have localized the psoriasis susceptibility 1 (PSORS1) locus to the
proximal major histocompatibility complex class I region, but approximately a dozen genes …

Non-pustular psoriasis consists of two disease subtypes, type I and type II, which
demonstrate distinct characteristics. Firstly the disease presents in different decades of life …

We have performed a genome scan, using markers spaced by 10 cM, in the search for
psoriasis-susceptibility loci. The family material of 134 affected sibling pairs was ascertained …

For a complex genetic disease, psoriasis has a high penetration within families and a
concordance rate of up to 70% in identical twins. Despite this and the endeavors of many …

Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility
locus in the major histocompatibility complex (MHC), to an∼ 300-kb region containing HLA …

Ten genome-wide scans have been conducted over the past few years in the search for
psoriasis susceptibility genes, but only one potential susceptibility region has been …