How to establish robust brain–behavior relationships without thousands of individuals

MD Rosenberg, ES Finn - Nature Neuroscience, 2022 - nature.com
Can studying individual differences in brain structure and function reveal individual
differences in behavior? Analyses of MRI data from nearly 50,000 individuals may suggest …

[HTML][HTML] Reproducible brain-wide association studies require thousands of individuals

S Marek, B Tervo-Clemmens, FJ Calabro, DF Montez… - Nature, 2022 - nature.com
Magnetic resonance imaging (MRI) has transformed our understanding of the human brain
through well-replicated mapping of abilities to specific structures (for example, lesion …

Toward a unified framework for interpreting machine-learning models in neuroimaging

L Kohoutová, J Heo, S Cha, S Lee, T Moon… - Nature protocols, 2020 - nature.com
Abstract Machine learning is a powerful tool for creating computational models relating brain
function to behavior, and its use is becoming widespread in neuroscience. However, these …

Task-free MRI predicts individual differences in brain activity during task performance

I Tavor, OP Jones, RB Mars, SM Smith, TE Behrens… - Science, 2016 - science.org
When asked to perform the same task, different individuals exhibit markedly different
patterns of brain activity. This variability is often attributed to volatile factors, such as task …

[HTML][HTML] Task-induced brain state manipulation improves prediction of individual traits

AS Greene, S Gao, D Scheinost… - Nature communications, 2018 - nature.com
Recent work has begun to relate individual differences in brain functional organization to
human behaviors and cognition, but the best brain state to reveal such relationships remains …

[HTML][HTML] Ten simple rules for predictive modeling of individual differences in neuroimaging

D Scheinost, S Noble, C Horien, AS Greene, EMR Lake… - NeuroImage, 2019 - Elsevier
Establishing brain-behavior associations that map brain organization to phenotypic
measures and generalize to novel individuals remains a challenge in neuroimaging …

Progress and challenges in probing the human brain

RA Poldrack, MJ Farah - Nature, 2015 - nature.com
Perhaps one of the greatest scientific challenges is to understand the human brain. Here we
review current methods in human neuroscience, highlighting the ways that they have been …

[PDF][PDF] Brain-behavior correlations: Two paths toward reliability

C Gratton, SM Nelson, EM Gordon - Neuron, 2022 - cell.com
In a recent issue of Nature, Marek et al.(2022) demonstrate that cross-sectional brain-
behavior correlations are often small and unreliable without large samples. This observation …

Cross-ethnicity/race generalization failure of behavioral prediction from resting-state functional connectivity

J Li, D Bzdok, J Chen, A Tam, LQR Ooi, AJ Holmes… - Science …, 2022 - science.org
Algorithmic biases that favor majority populations pose a key challenge to the application of
machine learning for precision medicine. Here, we assessed such bias in prediction models …

[HTML][HTML] Longitudinal test-retest neuroimaging data from healthy young adults in southwest China

W Liu, D Wei, Q Chen, W Yang, J Meng, G Wu, T Bi… - Scientific data, 2017 - nature.com
Multimodal magnetic resonance imaging (mMRI) has been widely used to map the structure
and function of the human brain, as well as its behavioral associations. However, to date, a …