Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the
World Health Organization and affects nearly six million (∼ 2.5% of the population) adults in …

The limited number of suitable animal models of bipolar disorder available for in-depth
behavioral, biochemical, histological, and pharmacological analysis is a rate-limiting step in …

The current pathophysiological understanding of mechanisms leading to onset and
progression of bipolar manic episodes remains limited. At the same time, available animal …

Bipolar disorder (BD) has been a particularly challenging illness for the development of
adequate animal models for neurobiological studies. These difficulties are largely related to …

Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients
suffering from this disorder experience dramatic mood swings with a wide variety of typical …

The state of animal models for bipolar disorder (BPD) is deficient, creating a major problem
in the research related to this devastating disorder and in our ability to translate molecular …

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …

Characterized by the switch of manic and depressive phases, bipolar disorder was
described as early as the fifth century BC. Nevertheless up to date, the underlying …

The scarcity of good animal models for bipolar disorder (BPD) and especially for mania is
repeatedly mentioned as one of the rate-limiting factors in the process of gaining a better …

According to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5),
the two major mood disorders are major depression (MD) and bipolar disorder (BD); …