Powerful ultrastructural tools are providing new insights into neuronal circuits, revealing a
wealth of anatomically‐defined synaptic connections. These wiring diagrams are …

In this Historical Perspective, we ask what information is needed beyond connectivity
diagrams to understand the function of nervous systems. Informed by invertebrate circuits …

BACKGROUND The human brain contains about 100 billion neurons, each of which makes
thousands of synaptic connections. Although individual neurons can themselves be …

The wide variety of animal behaviours that can be observed today arose through the
evolution of their underlying neural circuits. Advances in understanding the mechanisms …

Highlights•Drosophila larva enables combining comprehensive synapse resolution
connectivity maps with cellular-resolution activity maps and behavior maps.•This approach …

During postembryonic development, the nervous system must adapt to a growing body. How
changes in neuronal structure and connectivity contribute to the maintenance of appropriate …

Electrical coupling in circuits can produce non‐intuitive circuit dynamics, as seen in both
experimental work from the crustacean stomatogastric ganglion and in computational …

Circuits in the cerebral cortex consist of thousands of neurons connected by millions of
synapses. A precise understanding of these local networks requires relating circuit activity …

A central goal of modern neuroscience is to obtain a mechanistic understanding of higher
brain functions under healthy and diseased conditions. Addressing this challenge requires …

To understand the organization and assembly of mammalian brain circuits, we need a
comprehensive tool set that can address the challenges of cellular diversity, spatial …