Polycystin-1 (PC1) is an 11-transmembrane (TM) domain-containing protein encoded by the
PKD1 gene, the most frequently mutated gene leading to autosomal dominant polycystic …

Polycystin-1 (Pc1) cleavage at the G protein-coupled receptor (GPCR) proteolytic site (GPS)
is required for normal kidney morphology in humans and mice. We found a complex pattern …

Polycystin-1 (PC1) plays an essential role in renal tubular morphogenesis, and PC1
dysfunction causes human autosomal dominant polycystic kidney disease. A fundamental …

Polycystin-1 (PC1), a 4,303-amino acid integral membrane protein of unknown function,
interacts with polycystin-2 (PC2), a 968-amino acid α-type channel subunit. Mutations in …

Polycystin-1, whose mutation is the most frequent cause of autosomal dominant polycystic
kidney disease, is an extremely large and multi-faceted membrane protein whose primary or …

ABSTRACT Polycystin-1 (PC1) is encoded by PKD1, the principal gene mutated in
autosomal dominant polycystic kidney disease (ADPKD). The protein regulates terminal …

Mutations in genes encoding polycystin-1 (PC1) and polycystin-2 cause autosomal
dominant polycystic kidney disease. The polycystin protein family is composed of Ca2+ …

Polycystin-1 (PC1) has an essential function in renal tubular morphogenesis and disruption
of its function causes cystogenesis in human autosomal dominant polycystic kidney disease …

Polycystin (PC) 1 and PC2 are membrane proteins implicated in autosomal dominant
polycystic kidney disease. A physiologically relevant cleavage at PC1's G protein-coupled …

Autosomal dominant polycystic kidney disease (ADPKD) is a signalopathy of renal tubular
epithelial cells caused by naturally occurring mutations in two distinct genes, polycystic …