The treatment of musculoskeletal infections (MSIs), including periprosthetic joint infection
(PJI) and fracture-related infection (FRI), is often complicated by biofilm-related challenges …

Objectives Interest in phages as adjunctive therapy to treat difficult infections has grown in
the last decade. However, phage dosing and delivery for orthopedic infections have not …

Peri‐prosthetic joint infection (PJI) is one of the most serious and dreaded complications
after total joint replacement (TJR). Due to an aging population and the constant rise in …

Periprosthetic joint infection (PJI) is a significant challenge in orthopaedic surgery. Several
operations, protracted treatment, and the high associated morbidity have a very detrimental …

Bacterial resistance to antibiotics has catalysed interest in alternative antimicrobial
strategies. Bacteriophages (phages) are viruses of bacteria with a long history of successful …

There is a strong rationale for using phages in patients with bone and joint infections (BJIs).
Indeed, specific phages can infect and replicate in bacterial pathogens and have also …

Antibiotic resistance represents a key challenge of the 21st century. Since the pipeline of
new antibiotics in development is limited, the introduction of alternative antimicrobial …

Background Bacteriophage therapy has a long history in the treatment of musculoskeletal
and skin/soft tissue infections, particularly in the former Soviet Union. Due to the global rise …

Bone and joint infections are difficult to treat, and increasing antibiotic resistance has only
made them more challenging. This has led to renewed interest in phage therapy (PT). The …

Solutions for bone and joint infection (BJI) are needed where conventional treatments are
inadequate. Bacteriophages (phages) are naturally occurring viruses that infect bacteria and …