CXCR3 antagonist rescues ER stress and reduces inflammation and JEV infection in mice brain
A Singh, R Ghosh, P Guchhait - Cytokine, 2023 - Elsevier
The endoplasmic reticulum (ER) is crucial for maintaining cellular homeostasis, and
synthesis and folding of proteins and lipids. The ER is sensitive to stresses including viral …
synthesis and folding of proteins and lipids. The ER is sensitive to stresses including viral …
The role of CXCL1/CXCR2 axis in neurological diseases
S Jiang, J Liang, W Li, L Wang, M Song, S Xu… - International …, 2023 - Elsevier
The CXC chemokine ligand (CXCL) 1 and its receptor CXC chemokine receptor (CXCR) 2
are widely expressed in the peripheral nervous systems (PNS) and central nervous systems …
are widely expressed in the peripheral nervous systems (PNS) and central nervous systems …
CXCL8 as a potential therapeutic target for HIV-associated neurocognitive disorders
MK Mamik, A Ghorpade - Current drug targets, 2016 - ingentaconnect.com
Chemokine CXCL8 is a low molecular weight neutrophil chemoattractant implicated in
various neurodegenerative disorders including Alzheimer's disease and stroke. Increased …
various neurodegenerative disorders including Alzheimer's disease and stroke. Increased …
[HTML][HTML] Programming of neurotoxic cofactor CXCL-10 in HIV-1-associated dementia: abrogation of CXCL-10-induced neuro-glial toxicity in vitro by PKC activator
R Mehla, S Bivalkar-Mehla, M Nagarkatti… - Journal of …, 2012 - Springer
Background More than 50% of patients undergoing lifelong suppressive antiviral treatment
for HIV-1 infection develop minor HIV-1-associated neurocognitive disorders. Neurological …
for HIV-1 infection develop minor HIV-1-associated neurocognitive disorders. Neurological …
A potent and selective CXCR2 antagonist improves neuroimmune dysregulation through the inhibition of NF-κB and notch inflammatory signaling in the BTBR mouse …
Autism comprises a broad range of neurodevelopmental disorders characterized by social
communication deficits and repetitive and stereotyped behaviors. Chemokine receptor …
communication deficits and repetitive and stereotyped behaviors. Chemokine receptor …
[HTML][HTML] CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation
F Wu, Y Zhao, T Jiao, D Shi, X Zhu, M Zhang… - Journal of …, 2015 - Springer
Background Chemokines and chemokine receptors cooperate to promote immune cell
recruitment to the central nervous system (CNS). In this study, we investigated the roles of …
recruitment to the central nervous system (CNS). In this study, we investigated the roles of …
[HTML][HTML] Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after …
S Deng, P Jin, P Sherchan, S Liu, Y Cui… - Journal of …, 2021 - Springer
Background Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated
with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH …
with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH …
[HTML][HTML] CCR2 inhibition reduces neurotoxic microglia activation phenotype after Japanese encephalitis viral infection
Controlling the proinflammatory response of microglia by targeting chemokines (CC motif)
receptor 2 (CCR2) could be an important therapeutic approach for Japanese encephalitis …
receptor 2 (CCR2) could be an important therapeutic approach for Japanese encephalitis …
[HTML][HTML] CCR5 ameliorates Japanese encephalitis via dictating the equilibrium of regulatory CD4+Foxp3+ T and IL-17+CD4+ Th17 cells
JH Kim, AM Patil, JY Choi, SB Kim, E Uyangaa… - Journal of …, 2016 - Springer
Background CCR5 is a CC chemokine receptor involved in the migration of effector
leukocytes including macrophages, NK, and T cells into inflamed tissues. Also, the role of …
leukocytes including macrophages, NK, and T cells into inflamed tissues. Also, the role of …
Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice
C De Lemos, JE Christensen, A Nansen… - The Journal of …, 2005 - journals.aai.org
T cells play a key role in the control of viral infection in the CNS but may also contribute to
immune-mediated cell damage. To study the redundancy of the chemokine receptors …
immune-mediated cell damage. To study the redundancy of the chemokine receptors …