Ebola viral glycoprotein bound to its endosomal receptor Niemann-Pick C1
Summary Filoviruses, including Ebola and Marburg, cause fatal hemorrhagic fever in
humans and primates. Understanding how these viruses enter host cells could help to …
humans and primates. Understanding how these viruses enter host cells could help to …
Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies
The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral
internalization into endosomes, GP is cleaved by host cysteine proteases to expose a …
internalization into endosomes, GP is cleaved by host cysteine proteases to expose a …
Ebola virus entry requires the host‐programmed recognition of an intracellular receptor
EH Miller, G Obernosterer, M Raaben… - The EMBO …, 2012 - embopress.org
Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite
considerable efforts, no essential cellular receptors for filovirus entry have been identified …
considerable efforts, no essential cellular receptors for filovirus entry have been identified …
A new player in the puzzle of filovirus entry
JM White, KL Schornberg - Nature Reviews Microbiology, 2012 - nature.com
Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic
fever in primates, with extremely high fatality rates. Studies have focused on elucidating how …
fever in primates, with extremely high fatality rates. Studies have focused on elucidating how …
Ebolavirus Glycoprotein Directs Fusion through NPC1+ Endolysosomes
JA Simmons, RS D'Souza, M Ruas, A Galione… - Journal of …, 2016 - Am Soc Microbiol
Ebolavirus, a deadly hemorrhagic fever virus, was thought to enter cells through
endolysosomes harboring its glycoprotein receptor, Niemann-Pick C1. However, an …
endolysosomes harboring its glycoprotein receptor, Niemann-Pick C1. However, an …
Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding
The Ebola virus (EBOV) envelope glycoprotein (GP) is a membrane fusion machine required
for virus entry into cells. Following endocytosis of EBOV, the GP1 domain is cleaved by …
for virus entry into cells. Following endocytosis of EBOV, the GP1 domain is cleaved by …
Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes
MF Saeed, AA Kolokoltsov, T Albrecht… - PLoS …, 2010 - journals.plos.org
Zaire ebolavirus (ZEBOV), a highly pathogenic zoonotic virus, poses serious public health,
ecological and potential bioterrorism threats. Currently no specific therapy or vaccine is …
ecological and potential bioterrorism threats. Currently no specific therapy or vaccine is …
Structural basis for Marburg virus neutralization by a cross-reactive human antibody
T Hashiguchi, ML Fusco, ZA Bornholdt, JE Lee… - Cell, 2015 - cell.com
The filoviruses, including Marburg and Ebola, express a single glycoprotein on their surface,
termed GP, which is responsible for attachment and entry of target cells. Filovirus GPs differ …
termed GP, which is responsible for attachment and entry of target cells. Filovirus GPs differ …
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
Infections by the Ebola and Marburg filoviruses cause a rapidly fatal haemorrhagic fever in
humans for which no approved antivirals are available. Filovirus entry is mediated by the …
humans for which no approved antivirals are available. Filovirus entry is mediated by the …
Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion
Background Ebolavirus belongs to the family filoviridae and causes severe hemorrhagic
fever in humans with 50–90% lethality. Detailed understanding of how the viruses attach to …
fever in humans with 50–90% lethality. Detailed understanding of how the viruses attach to …