It is generally recognised that novel antiviral drugs, less prone to resistance, would be a
desirable alternative to current drug options in order to be able to treat potentially serious …

Seasonal and pandemic influenza viruses continue to be a leading global health concern.
Emerging resistance to the current drugs and the variable efficacy of vaccines underscore …

Emerging influenza viruses are a serious threat to human health because of their pandemic
potential. A promising target for the development of novel anti-influenza therapeutics is the …

Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

Highlights•The structures of influenza polymerase allow the identification of novel anti-
influenza drugs.•The inhibitors targeting influenza polymerase are discussed.•The screening …

Highly pathogenic influenza virus strains currently in circulation pose a significant risk of a
global pandemic. Following the reported crystal structure of the endonuclease domain from …

The influenza virus RNA-dependent RNA polymerase is a heterotrimeric complex (PA, PB1
and PB2) with multiple enzymatic activities for catalyzing viral RNA transcription and …

The influenza virus RNA-dependent RNA polymerase complex (RdRp), a heterotrimeric
protein complex responsible for viral RNA transcription and replication, represents a primary …

Assembly of the heterotrimeric influenza virus polymerase complex from the individual
subunits PB1, PA, and PB2 is a prerequisite for viral replication, in which the interaction …

Influenza viruses are the cause of yearly epidemics and occasional pandemics that
represent a significant challenge to public health. Current control strategies are imperfect …