Compromised bone-regenerating capability following a long bone fracture is often the result
of reduced host bone marrow (BM) progenitor cell numbers and efficacy. Without surgical …

The enhancement of bone regeneration with biological agents including osteogenic growth
factors and mesenchymal stem cells (MSCs) is becoming a clinical reality. Many exciting …

Mesenchymal stem cells (MSCs) are non-haematopoietic stromal stem cells that have many
sources, such as bone marrow, periosteum, vessel walls, adipose, muscle, tendon …

Significance: Mesenchymal stem cells (MSCs) play a key role in fracture repair by
differentiating to become bone-forming osteoblasts and cartilage-forming chondrocytes …

The maintenance of stable bone mass during adult life, following rapid skeletal growth
during childhood, is the result of a carefully controlled balance between the activities of bone …

Failure of bone repair is a challenging problem in the management of fractures. There is a
limited supply of autologous bone grafts for treating nonunions, with associated morbidity …

Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

Despite advances in biomedical research, fracture nonunion rates have remained stable
throughout the years. Long-bone fractures have a high likelihood of nonunion, but the …

Bone possesses the intrinsic regeneration capacity as part of the repair process in response
to injury, during skeletal development or continuous remodeling throughout adult life …

Mesenchymal progenitor cells (MPCs) are nonhematopoietic multipotent cells capable of
differentiating into mesenchymal and nonmesenchymal lineages. While they can be isolated …