Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse
species; however, its effect on resistance to illness and mortality in primates has not been …

These findings include CR-induced attenuation of age changes in plasma triglycerides (2)
and melatonin (3) as well as oxidative damage (4) and glucose tolerance (5). Current …

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been
shown that fasting for a portion of each day has metabolic benefits and promotes lifespan …

The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs
in growth, reproduction, and immune defense that make it difficult to identify therapeutically …

Caloric restriction has been shown to increase longevity in organisms ranging from yeast to
mammals. In some organisms, this has been associated with a decreased fat mass and …

Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition,
decelerates the rate of aging and the development of age-related diseases. CR has been …

Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported
as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is …

It is widely held that caloric restriction (CR) extends lifespan by preventing or reducing the
age-related accumulation of irreversible molecular damage. In contrast, our results suggest …

Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its
beneficial effects remain unknown. The manner in which CR has been implemented in …