The filoviruses, including ebolaviruses and marburgviruses, are among the world's deadliest
pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is …

Highlights•Filovirus neutralization and protection is related to epitope on filovirus GPs.•GP
epitopes on marburgvirus and ebolavirus differ fundamentally at a structural …

Filoviruses (family Filoviridae) include five ebolaviruses and Marburg virus. These
pathogens cause a rapidly progressing and severe viral disease with high mortality rates …

Highlights•Several structures are now available of broadly reactive antibodies in complex
with GP.•Many broadly reactive antibodies bind along the 'waist'of GP in three primary …

The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has
highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody …

Filoviruses cause highly lethal viral hemorrhagic fever in humans and nonhuman primates.
Current immunotherapeutic options for filoviruses are mostly specific to Ebola virus (EBOV) …

Filoviruses, including ebolaviruses and marburgviruses, can cause severe and often fatal
disease in humans. Over the past several years, antibody therapy has emerged as a …

Monoclonal antibodies (mAbs) have proven effective for the treatment of ebolavirus infection
in humans, with two mAb-based drugs Inmazeb™ and Ebanga™ receiving FDA approval in …

The glycoprotein (GP) of ebolaviruses participates in a critical membrane fusion process to
establish infection of a cell and therefore, represents an important target of both vaccines …

The filoviruses, which include the marburg-and ebolaviruses, have caused multiple
outbreaks among humans this decade. Antibodies against the filovirus surface glycoprotein …