COVID-19 drug discovery and treatment options

JFW Chan, S Yuan, H Chu, S Sridhar… - Nature Reviews …, 2024 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused substantial morbidity and …

COVID-19 therapeutics: Challenges and directions for the future

PC Robinson, DFL Liew, HL Tanner… - Proceedings of the …, 2022 - National Acad Sciences
The emergence of SARS-CoV-2 triggering the COVID-19 pandemic ranks as arguably the
greatest medical emergency of the last century. COVID-19 has highlighted health disparities …

A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals

VC Chitalia, AH Munawar - Journal of translational medicine, 2020 - Springer
While the COVID-19 pandemic has spurred intense research and collaborative discovery
worldwide, the development of a safe, effective, and targeted antiviral from the ground up is …

Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Revisiting potential druggable targets against SARS‐CoV‐2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review

AAM Sohag, MA Hannan, S Rahman… - Drug development …, 2020 - Wiley Online Library
Abstract Coronavirus disease‐19 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), is one of the most contagious diseases in human …

An Update on SARS-CoV-2 Clinical Trial Results—What We Can Learn for the Next Pandemic

BY Arman, J Brun, ML Hill, N Zitzmann… - International Journal of …, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic has claimed over 7 million lives
worldwide, providing a stark reminder of the importance of pandemic preparedness. Due to …

COVID-19: a defining moment for clinical pharmacology?

PH van der Graaf, KM Giacomini - 2020 - cabidigitallibrary.org
Though most drug development takes years from discovery to approval, for the COVID-19
pandemic, drug development is on a fundamentally different timeline. Broadly speaking …

Therapeutics for COVID-19

SS Toussi, JL Hammond, BS Gerstenberger… - Nature …, 2023 - nature.com
Vaccines and monoclonal antibody treatments to prevent severe coronavirus disease 2019
(COVID-19) illness were available within a year of the pandemic being declared but there …

Current and future therapeutical approaches for COVID-19

Y Duan, Y Yao, SA Kumar, HL Zhu, J Chang - Drug Discovery Today, 2020 - Elsevier
Coronavirus 2019 (COVID-19), the WHO-classified novel coronavirus of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global pandemic …

Update on antiviral strategies against COVID-19: unmet needs and prospects

CH Liu, CH Lu, SH Wong, LT Lin - Frontiers in Immunology, 2021 - frontiersin.org
By December 2020, the COVID-19 pandemic had caused more than 74 million confirmed
cases and 1.6 million related deaths around the world. However, only a few drugs have …