Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA. 5 Omicron variant in mice

SM Scheaffer, D Lee, B Whitener, B Ying, K Wu… - Nature medicine, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
in the Omicron lineage has resulted in diminished Coronavirus Disease 2019 (COVID-19) …

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

B Ying, B Whitener, LA VanBlargan… - Science translational …, 2021 - science.org
Although mRNA vaccines encoding the spike protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) prevent COVID-19, the emergence of new viral variants …

[HTML][HTML] Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice

B Ying, SM Scheaffer, B Whitener, CY Liang… - Cell, 2022 - cell.com
The large number of spike substitutions in Omicron lineage variants (BA. 1, BA. 1.1., and BA.
2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We evaluated in mice the …

A booster dose of Delta× Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

IJ Lee, CP Sun, PY Wu, YH Lan, IH Wang… - Journal of biomedical …, 2022 - Springer
Background With the continuous emergence of new SARS-CoV-2 variants that feature
increased transmission and immune escape, there is an urgent demand for a better vaccine …

Low neutralization of SARS-CoV-2 Omicron BA. 2.75. 2, BQ. 1.1 and XBB. 1 by parental mRNA vaccine or a BA. 5 bivalent booster

C Kurhade, J Zou, H Xia, M Liu, HC Chang, P Ren… - Nature medicine, 2023 - nature.com
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron sublineages, including the BA. 2-derived BA. 2.75. 2 and the BA. 5-derived BQ. 1.1 …

Original SARS-CoV-2 monovalent and Omicron BA. 4/BA. 5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results

S Chalkias, JL Whatley, F Eder, B Essink, S Khetan… - Nature Medicine, 2023 - nature.com
This ongoing, open-label, phase 2/3 trial compared the safety and immunogenicity of the
Omicron BA. 4/BA. 5-containing bivalent mRNA-1273.222 vaccine with the ancestral Wuhan …

[HTML][HTML] Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination

E Pérez-Then, C Lucas, VS Monteiro, M Miric… - Nature medicine, 2022 - nature.com
The recent emergence of the SARS-CoV-2 Omicron variant is raising concerns because of
its increased transmissibility and its numerous spike mutations, which have the potential to …

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

WF Garcia-Beltran, KJS Denis, A Hoelzemer, EC Lam… - Cell, 2022 - cell.com
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …

Omicron-specific mRNA vaccine induced potent neutralizing antibody against Omicron but not other SARS-CoV-2 variants

IJ Lee, CP Sun, PY Wu, YH Lan, IH Wang, WC Liu… - BioRxiv, 2022 - biorxiv.org
The emerging SARS-CoV-2 variants of concern (VOC) harbor mutations associated with
increasing transmission and immune escape, hence undermine the effectiveness of current …

[HTML][HTML] Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

K Wu, A Choi, M Koch, S Elbashir, LZ Ma, D Lee… - Vaccine, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of a
global pandemic. Safe and effective COVID-19 vaccines are now available, including mRNA …