Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

One of the most significant challenges of cell biology is to understand how each type of cell
copes with its specific workload without suffering damage. Among the most intriguing …

The intestinal mucosal barrier is the first line to defense against luminal content penetration
and performs numerous biological functions. The intestinal epithelium contains a huge …

One of the most significant challenges of inflammatory bowel disease (IBD) research is to
understand how alterations in the symbiotic relationship between the genetic composition of …

The intestinal mucosa is a site of multiple stressors and forms the barrier between the
internal and external environment. In the intestine, a complex interplay between the …

Autophagy is an evolutionarily conserved catabolic process that involves the invagination
and degradation of cytoplasmic components through an autophagosomelysosome track …

Autophagy degrades the cytoplasmic contents engulfed by autophagosomes. Besides
providing energy and building blocks during starvation via random degradation, autophagy …

The intestinal epithelial tight junctions (TJs) provide barrier against paracellular permeation
of lumenal antigens. Defects in TJ barrier such as increased levels of pore-forming TJ …

Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that
targets cytoplasmic materials including cytosol, macromolecules and unwanted organelles …

The discovery of numerous genetic variants in the human genome that are associated with
inflammatory bowel disease (IBD) has revealed critical pathways that play important roles in …