Intranasal administration of convalescent plasma protects against SARS-CoV-2 infection in hamsters

E Wouters, C Verbrugghe, R Abdelnabi, R Devloo… - …, 2023 - thelancet.com
Background Convalescent plasma (CP) transfusion is an early option for treating infections
with pandemic potential, often preceding vaccine or antiviral drug rollout. Heterogenous …

SARS-CoV-2 infection of rhesus macaques treated early with human COVID-19 convalescent plasma

JD Deere, TD Carroll, J Dutra, L Fritts… - Microbiology …, 2021 - Am Soc Microbiol
Human clinical studies investigating use of convalescent plasma (CP) for treatment of
coronavirus disease 2019 (COVID-19) have produced conflicting results. Outcomes in these …

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but …

KKA Van Rompay, KJ Olstad, RL Sammak… - PLoS …, 2022 - journals.plos.org
Early in the SARS-CoV-2 pandemic, there was a high level of optimism based on
observational studies and small controlled trials that treating hospitalized patients with …

Early mortality benefit with COVID‐19 convalescent plasma: a matched control study

AG Shenoy, AZ Hettinger, SJ Fernandez… - British journal of …, 2021 - Wiley Online Library
Convalescent plasma can provide passive immunity during viral outbreaks, but the benefit is
uncertain for the treatment of novel coronavirus disease 2019 (COVID‐19). Our goal is to …

The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study

K Duan, B Liu, C Li, H Zhang, T Yu, J Qu, M Zhou… - MedRxiv, 2020 - medrxiv.org
Currently, there are no approved specific antiviral agents for 2019 novel coronavirus
disease (COVID-19). In this study, ten severe patients confirmed by real-time viral RNA test …

Safety and efficacy of convalescent plasma for severe COVID-19: a randomized, single blinded, parallel, controlled clinical study

M Rojas, Y Rodríguez, JC Hernández… - BMC Infectious …, 2022 - Springer
Background Convalescent plasma (CP) has been widely used to treat COVID-19 and is
under study. However, the variability in the current clinical trials has averted its wide use in …

How do I implement an outpatient program for the administration of convalescent plasma for COVID‐19?

EM Bloch, AAR Tobian, S Shoham, DF Hanley… - …, 2022 - Wiley Online Library
Convalescent plasma, collected from donors who have recovered from a pathogen of
interest, has been used to treat infectious diseases, particularly in times of outbreak, when …

Experience with COVID‐19 convalescent plasma provides vital guidance to future pandemics

J Hartmann, EM Bloch, T Burnouf - Transfusion, 2022 - Wiley Online Library
Convalescent plasma (CP) has been used to treat emerging infectious diseases for over a
century. It was notably deployed during the 1918 flu pandemic and has been explored …

[HTML][HTML] Administration of vaccine-boosted COVID-19 convalescent plasma to SARS-CoV-2 infected hamsters decreases virus replication in lungs and hastens …

TD Carroll, T Wong, MK Morris, C Di Germanio, Z Ma… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The utility of COVID-19 convalescent plasma (CCP) for treatment of immunocompromised
patients who are not able to mount a protective antibody response against SARS-CoV-2 and …

[HTML][HTML] Randomized controlled trial transfusing convalescent plasma as post-exposure prophylaxis against SARS-CoV-2 infection

S Shoham, EM Bloch, A Casadevall, D Hanley, B Lau… - medRxiv, 2021 - ncbi.nlm.nih.gov
BACKGROUND: The efficacy of SARS-CoV-2 convalescent plasma (CCP) for preventing
infection in exposed, uninfected individuals is unknown. We hypothesized that CCP might …