The role of inorganic phosphate transporters in highly proliferative cells: from protozoan parasites to cancer cells

MA Lacerda-Abreu, CF Dick, JR Meyer-Fernandes - Membranes, 2022 - mdpi.com
In addition to their standard inorganic phosphate (Pi) nutritional function, Pi transporters
have additional roles in several cells, including Pi sensing (the so-called transceptor) and a …

The roles of sodium-independent inorganic phosphate transporters in inorganic phosphate homeostasis and in cancer and other diseases

MA Lacerda-Abreu, T Russo-Abrahão… - International Journal of …, 2020 - mdpi.com
Inorganic phosphate (Pi) is an essential nutrient for the maintenance of cells. In healthy
mammals, extracellular Pi is maintained within a narrow concentration range of 0.70 to 1.55 …

Inorganic phosphate uptake in unicellular eukaryotes

CF Dick, ALA Dos-Santos… - Biochimica et Biophysica …, 2014 - Elsevier
Background Inorganic phosphate (P i) is an essential nutrient for all organisms. The route of
P i utilization begins with P i transport across the plasma membrane. Scope of review Here …

Inorganic phosphate (Pi) in the breast cancer microenvironment: Production, transport and signal transduction as potential targets for anticancer strategies

MA Lacerda-Abreu… - Current Cancer Drug …, 2023 - ingentaconnect.com
Tumor cells develop a high demand for inorganic phosphate (Pi) due to their high growth
rates and energy requirements. Serum Pi concentrations in cancer patients have been found …

Inorganic phosphate transporters in cancer: Functions, molecular mechanisms and possible clinical applications

MA Lacerda-Abreu, T Russo-Abrahão… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Inorganic phosphate is one of the most essential nutrients for the maintenance of cell life.
Because of its essential role in nutrient supplementation, the study of plasma membrane …

[HTML][HTML] H+-dependent inorganic phosphate transporter in breast cancer cells: Possible functions in the tumor microenvironment

MA Lacerda-Abreu, T Russo-Abrahão… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Tumor microenvironment has a high concentration of inorganic phosphate (Pi), which is
actually a marker for tumor progression. Regarding Pi another class of transporter has been …

Interstitial inorganic phosphate as a tumor microenvironment marker for tumor progression

AA Bobko, TD Eubank, B Driesschaert, I Dhimitruka… - Scientific reports, 2017 - nature.com
Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters
such as oxygen (p O2), extracellular acidosis (pHe), and concentration of interstitial …

Tumour metastasis as an adaptation of tumour cells to fulfil their phosphorus requirements

CCCR de Carvalho, MJ Caramujo - Medical hypotheses, 2012 - Elsevier
Inorganic phosphate (Pi) is a vital component of nucleotides, membrane phospholipids, and
phosphorylated intermediates in cellular signalling. The Growth Rate Hypothesis (GRH) …

Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT

Y Liu, C Li, M Gupta, N Verma… - Proceedings of the …, 2021 - National Acad Sciences
Phosphate is an indispensable metabolite in a wide variety of cells and is involved in
nucleotide and lipid synthesis, signaling, and chemical energy storage. Proton-coupled …

Investigating the role of inorganic phosphate in tumor metabolism and metastasis

CP Ramirez, D Fiedler - Cancer & Metabolism, 2014 - Springer
Background Altered cell metabolism is regarded as a hallmark of cancer with numerous
studies highlighting glucose and glutamine as critical nutrients for tumor proliferation …