The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota

G Annunziata, A Sureda, IE Orhan, M Battino… - Neuroscience & …, 2021 - Elsevier
Neurodegenerative disorders, particularly in the elderly population, represent one of the
most pressing social and health-care problems in the world. Besides the well-established …

Polyphenols-gut microbiota interplay and brain neuromodulation

S Filosa, F Di Meo, S Crispi - Neural regeneration research, 2018 - journals.lww.com
Increasing evidence suggests that food ingested polyphenols can have beneficial effects in
neuronal protection acting against oxidative stress and inflammatory injury. Moreover …

Impact of gut microbiota in brain ageing: polyphenols as beneficial modulators

F Sarubbo, D Moranta, S Tejada, M Jiménez… - Antioxidants, 2023 - mdpi.com
Brain ageing is a complex physiological process that includes several mechanisms. It is
characterized by neuronal/glial dysfunction, alterations in brain vasculature and barriers …

Neuro-Nutraceutical Polyphenols: How Far Are We?

MT Gentile, I Camerino, L Ciarmiello, P Woodrow… - Antioxidants, 2023 - mdpi.com
The brain, composed of billions of neurons, is a complex network of interacting dynamical
systems controlling all body functions. Neurons are the building blocks of the nervous …

Does the GUT microbial metabolome really matter? The connection between GUT metabolome and neurological disorders

MA Marć, R Jastrząb, J Mytych - Nutrients, 2022 - mdpi.com
Herein we gathered updated knowledge regarding the alterations of gut microbiota
(dysbiosis) and its correlation with human neurodegenerative and brain-related diseases …

The dichotomous role of the gut microbiome in exacerbating and ameliorating neurodegenerative disorders

U Raval, JM Harary, E Zeng… - Expert review of …, 2020 - Taylor & Francis
Introduction Age related neurodegenerative disorders affect millions of people around the
world. The role of the gut microbiome (GM) in neurodegenerative disorders has been …

Dietary polyphenols: A novel strategy to modulate microbiota-gut-brain axis

D Serra, LM Almeida, TCP Dinis - Trends in food science & technology, 2018 - Elsevier
Background Although great advances have been made in the discovery of new drugs that
effectively penetrate the brain and alleviate neurological disorders, such as Alzheimer's …

Dietary polyphenols represent a phytotherapeutic alternative for gut dysbiosis associated neurodegeneration: A Systematic review

A Chatterjee, S Kumar, SR Sarkar, R Halder… - The Journal of …, 2024 - Elsevier
Globally, neurodegeneration and cerebrovascular disease are common and growing
causes of morbidity and mortality. Pathophysiology of this group of diseases encompasses …

A new concept of associations between gut microbiota, immunity and central nervous system for the innovative treatment of neurodegenerative disorders

S Yoshikawa, K Taniguchi, H Sawamura, Y Ikeda… - Metabolites, 2022 - mdpi.com
Nerve cell death accounts for various neurodegenerative disorders, in which altered
immunity to the integrated central nervous system (CNS) might have destructive …

New therapeutic drugs from bioactive natural molecules: the role of gut microbiota metabolism in neurodegenerative diseases

F Di Meo, S Donato, A Di Pardo… - Current drug …, 2018 - ingentaconnect.com
Background: The gut-brain axis is considered a neuroendocrine system, which connects the
brain and gastrointestinal tract and plays an important role in stress response. The …