The anti-viral pattern recognition receptor STING and its partnering cytosolic DNA sensor
cGAS have been increasingly recognized to respond to self DNA in multiple pathologic …

Stimulator of interferon genes (STING) has emerged as a key regulator of innate immunity,
recognizing intracellular exogenous and endogenous DNA. Recent findings reveal that …

DNA is present in the nucleus and mitochondria of eukaryotic cells. There are, however,
certain instances in which DNA emerges in the cytosol. The two major sources of cytosolic …

Recent studies have revealed the diverse pathophysiological functions of mitochondria
beyond traditional energetic metabolism in cells. Mitochondria‐released damage …

Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely
probe the local environment and maintain host integrity. Besides pathogen recognition …

Resistance to DNA-damaging agents is a significant cause of treatment failure and poor
outcomes in oncology. To identify unrecognized regulators of cell survival we performed a …

DNA that gains access to the cytoplasm generally serves as a danger signal for the hosts.
An emerging paradigm for responding to cytosolic DNA s centres on the endoplasmic …

One of the oldest mechanisms of immune defense against pathogens is through detection of
foreign DNA. Since human DNA is compartmentalized into the nucleus, its presence in the …

SnapShot: CGAS-STING Signaling Page 1 3 Cell ???, ??MONTH?? ??DATE??, 200? ©200?
Elsevier Inc. DOI XXXXXXXXX See online version for ??????. S n a pS h o t: XXX X X X XX …

The cyclic guanosine monophosphate–adenosine monophosphate (GMP‐AMP) synthase‐
Stimulator of Interferon Genes (cGAS‐STING) pathway is a critical innate immune …