Fast and selective isolation of single cells with unique spatial and morphological traits
remains a technical challenge. Here, we address this by establishing high-speed image …

Intelligent image-activated cell sorting (iIACS) is a machine-intelligence technology that
performs real-time intelligent image-based sorting of single cells with high throughput. iIACS …

Unraveling the genetic and epigenetic determinants of phenotypes is critical for
understanding and re-engineering biology and would benefit from improved methods to …

Cell classification based on phenotypical, spatial, and genetic information greatly advances
our understanding of the physiology and pathology of biological systems. Technologies …

Genome-scale functional genetic screens are used to identify key genetic regulators of a
phenotype of interest. However, the identification of genetic modifications that lead to a …

Microscopy is a powerful tool for characterizing complex cellular phenotypes, but linking
these phenotypes to genotype or RNA expression at scale remains challenging. Here, we …

Multimodal single-cell assays provide high-resolution snapshots of complex cell
populations, but are mostly limited to transcriptome plus an additional modality. Here, we …

Image-based screening is used to measure a variety of phenotypes in cells and whole
organisms. Combined with perturbations such as RNA interference, small molecules, and …

Discovery of the genetic components underpinning fundamental and disease-related
processes is being rapidly accelerated by combining efficient, programmable genetic …

Assigning functions to genes and learning how to control their expression are part of the
foundation of cell biology and therapeutic development. An efficient and unbiased method to …