The hantavirus surface glycoprotein lattice and its fusion control mechanism

A Serris, R Stass, EA Bignon, NA Muena… - Cell, 2020 - cell.com
Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for
which no treatment is available. Hantavirus particles are pleomorphic and display a …

Molecular organization and dynamics of the fusion protein Gc at the hantavirus surface

EA Bignon, A Albornoz, P Guardado-Calvo, FA Rey… - Elife, 2019 - elifesciences.org
The hantavirus envelope glycoproteins Gn and Gc mediate virion assembly and cell entry,
with Gc driving fusion of viral and endosomal membranes. Although the X-ray structures and …

The surface glycoproteins of hantaviruses

P Guardado-Calvo, FA Rey - Current Opinion in Virology, 2021 - Elsevier
Hantaviruses are rodent-borne viruses distributed worldwide, transmitted through the air and
with the ability to spread from person to person. They maintain a non-symptomatic persistent …

Hantavirus Gn and Gc envelope glycoproteins: key structural units for virus cell entry and virus assembly

N Cifuentes-Muñoz, N Salazar-Quiroz, ND Tischler - Viruses, 2014 - mdpi.com
In recent years, ultrastructural studies of viral surface spikes from three different genera
within the Bunyaviridae family have revealed a remarkable diversity in their spike …

A molecular-level account of the antigenic hantaviral surface

S Li, I Rissanen, A Zeltina, J Hepojoki, J Raghwani… - Cell reports, 2016 - cell.com
Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection
through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the …

Structural transitions of the conserved and metastable hantaviral glycoprotein envelope

I Rissanen, R Stass, A Zeltina, S Li, J Hepojoki… - Journal of …, 2017 - Am Soc Microbiol
Hantaviruses are zoonotic pathogens that cause severe hemorrhagic fever and pulmonary
syndrome. The outer membrane of the hantavirus envelope displays a lattice of two …

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

E Mittler, A Serris, ES Esterman, C Florez… - Science translational …, 2023 - science.org
Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved
vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody …

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

TB Engdahl, E Binshtein, RL Brocato, NA Kuzmina… - Elife, 2023 - elifesciences.org
Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to
humans by aerosolized excreta or, in rare cases, person-to-person contact. While infections …

Humoral immunity to hantavirus infection

TB Engdahl, JE Crowe Jr - MSphere, 2020 - Am Soc Microbiol
Hantaviruses are zoonotic pathogens found in parts of Europe, Asia, South America, and
North America, which can cause renal and respiratory failure with fatality rates up to 40 …

Hantavirus Gn and Gc glycoproteins self-assemble into virus-like particles

R Acuña, N Cifuentes-Muñoz, CL Márquez… - Journal of …, 2014 - Am Soc Microbiol
How hantaviruses assemble and exit infected cells remains largely unknown. Here, we
show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn and Gc …