Introduction: The development of ophthalmic formulations able to deliver hydrophilic and
hydrophobic drugs to the inner structures of the eye and restore the preocular tear film has …

Topical route of administration is the most commonly used method for the treatment of
ophthalmic diseases. However, presence of several layers of permeation barriers starting …

Liposomes are microscopic vesicles composed of membrane-like lipid bilayers surrounding
aqueous compartments. This unique feature imparts the ability of liposomes to encapsulate …

The eye is one of the most specialized organs in the body; one of its flawless functions is
vigorously controlling the foreign materials' entrance to the eye. On the other hand, this …

During the past decade liposomes have been investigated extensively for their ability to
improve drug utilization by the body, first in the area of chemotherapeutics and most recently …

Liposomal formulations were significantly explored over the last decade for the ophthalmic
drug delivery applications. These formulations are mainly composed of phosphatidylcholine …

Poor drug delivery to lesions in patients' eyes is a major obstacle to the treatment of ocular
diseases. The accessibility of these areas to drugs is highly restricted by the presence of …

Ocular barriers and the poor water solubility of drug candidates present a number of
problems for the development of ocular drug delivery systems. Recently, the emergence of …

Due to the multiple barriers imposed by the eye against the penetration of drugs, the ocular
delivery and targeting are considered difficult to achieve. A major challenge in ocular drug …

Delivery of drugs to eyes is a great challenge to researchers because of a number of
barriers in the eye preventing the actual dose from reaching the site. A number of ophthalmic …