The past decade has revealed that melanoma is comprised of multiple subclasses that can
be categorized on the basis of key features, including the clinical stage of disease, the …

The incidence of melanoma is increasing at one of the highest rates of any form of cancer in
the United States, with the current lifetime risk being one in 68. At present, there are limited …

We have recently witnessed an explosion in our understanding of melanoma. Knowledge of
the molecular basis of melanoma and the successes of targeted therapies have pushed …

In the initial period after melanoma was recognised as a disease entity in the early 1800's, it
was subclassified on the basis of its presumed origin (from a precursor naevus, from a …

Metastatic melanoma remained for decades without any effective treatment and was thus
considered as a paradigm of cancer resistance. Recent progress with understanding of the …

Melanoma is a relentless type of skin cancer which involves myriad signaling pathways
which regulate many cellular processes. This makes melanoma difficult to treat, especially …

Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …

This review aims to summarize the current knowledge of molecular pathways and their
clinical relevance in melanoma. Metastatic melanoma was a grim diagnosis, but in recent …

Malignant melanoma remains one of the fastest growing cancers worldwide. Although the
primary cutaneous melanoma can be managed by surgery, the advanced metastatic …

High-throughput sequencing technologies are providing new insights into the genetic
alterations involved in melanomagenesis. It appears likely that most genetic events …