Effector T cells leave the lymph nodes armed with specialized functional attributes. Their
antigenic targets may be located anywhere in the body, posing the ultimate challenge: how …

T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …

T cells play a key role in the battle against cancer. To perform their antitumor activities, T
cells need to adequately respond to tumor antigens by establishing contacts with either …

Effector T cell migration through tissues can enable control of infection or mediate
inflammatory damage. Nevertheless, the molecular mechanisms that regulate migration of …

Naive and effector/memory T cells have distinct repertoires of trafficking ligands and
receptors that restrict their ability to interact with specialized microvessels in different …

Adaptive immunity is initiated by T cell recognition of foreign peptides presented on dendritic
cells (DCs) by major histocompatibility molecules. These interactions take place in …

Trafficking of CD8 T cells, in both the steady-state and during episodes of infection or
inflammation, is a highly dynamic process and involves a variety of receptor–ligand …

Leukocytes must traverse inflamed tissues to effectively control local infection. Although
motility in dense tissues seems to be integrin independent and based on actomyosin …

T cells function locally. Accordingly, T cells' recognition of antigen, their subsequent
activation and differentiation, and their role in the processes of infection control, tumour …

Activated T cells must mediate effector responses sufficiently to clear pathogens while
avoiding excessive tissue damage. Here we have combined dynamic intravital microscopy …