In hypoxic dendritic cells (DCs), a low level of Zn2+ can induce the activation of
immunogenic DCs (igDCs), thereby triggering an active T-cell response to propel the …

Accumulating evidence suggests that activation of proinflammatory M1-type macrophages in
the synovium plays a vital role in the progression of osteoarthritis (OA). Redundant nitric …

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the lining of the
synovial joints and approximately affects 0.5− 1% of the total population imposing a …

Inflammatory infiltration and bone destruction are important pathological features of
rheumatoid arthritis (RA), which originate from the disturbed niche of macrophages. Here …

Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease that results in
synovitis, cartilage destruction, and even loss of joint function. The frequent and long-term …

Zinc oxide nanoparticles (ZnONPs) are inorganic nano-biomaterials with excellent
antimicrobial properties. However, their effects on the anti-infection ability of the innate …

Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease
that is characterized by alterations in the balance between effector and regulatory CD4+ T …

Based on the pathological characteristics of rheumatoid arthritis, including the
overproduction of reactive oxygen species (ROS), inflammatory responses, and osteoclast …

Aim: To assess the mechanistic effects of cerium oxide nanoparticles (CONPs) on Freund's
complete adjuvant (FCA)-induced rheumatoid arthritis in rats. Methods: CONPs were …

Immunotherapies have shown high clinical success, however, the therapeutical efficacy is
largely restrained by insufficient immune activation and an immunosuppressive …