Simple Summary Mutations in the tumor suppressor p53 (p53) occur in~ 50% of human
cancers, the majority of which are missense mutations. Mutations in p53 not only impair the …

Simple Summary The tumor suppressor protein p53 is frequently mutated in human cancers,
and its reactivation represents an encouraging hope for precision anticancer therapy …

TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …

Among genetic alterations in human cancers, mutations in the tumor suppressor p53 gene
are the most common, occurring in over 50% of human cancers. The majority of p53 …

The tumor suppressor p53 is lost or mutated in approximately half of human cancers. Mutant
p53 not only loses its anti-tumor transcriptional activity, but also often acquires oncogenic …

TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding
transcription factor activated by stressful stimuli; it upregulates target genes involved in …

TP53, which encodes the tumour-suppressor protein p53, is the most frequently mutated
gene across all cancer types. The presence of mutant p53 predisposes to cancer …

Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to
restore the functionality of p53 in tumours as a therapeutic strategy began decades ago …

Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all,
human cancers. Loss of functional wild-type p53 is achieved via two main mechanisms …