Dry eye disease (DED) is a common, multifactorial ocular condition with major impact on
vision and quality of life. It is now well recognized that the pathophysiology of chronic DED …

Purpose: Dry eye disease (DED) is a prevalent inflammatory disorder of the lacrimal
functional unit of multifactorial origin leading to chronic ocular surface disease, impaired …

Purpose: The purpose of this article is to review the evidence for the hypothesis that the core
mechanism of dry eye disease (DED) is inflammation, including evidence from recent basic …

Ocular surface inflammation is propagated by a complex series of molecular processes and
has been implicated in the pathogenesis of dry eye disease (DED), either as a causal or a …

The immune system plays a central role in protecting the ocular surface from exogenous and
endogenous insults, maintaining tissue homeostasis thanks to the mechanism of para …

PURPOSE: The goal of this literature review is to discuss recent discoveries in the
pathophysiology of dry eye and the subsequent evolution of diagnostic and management …

Keratoconjunctivitis sicca, or dry eye, is a common ocular disease prompting millions of
individuals to seek ophthalmological care. Regardless of the underlying etiology, dry eye …

This article reviews the literature and summarizes the role of inflammation in dry eye
disease. A PubMed search was performed using the keywords inflammatory cycle and dry …

Purpose: Dry eye is a major ocular pathology worldwide. Although dry eye is a multifactorial
disease, recent studies have shown that chronic immunologic processes have a pivotal role …

Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular
immune response comprising innate and adaptive phases. When the ocular immune system …