Discovery of Lactomodulin, a Unique Microbiome-Derived Peptide That Exhibits Dual Anti-Inflammatory and Antimicrobial Activity against Multidrug-Resistant …

WK Mousa, R Ghemrawi, T Abu-Izneid… - International journal of …, 2023 - mdpi.com
The human body is a superorganism that harbors trillions of microbes, most of which inhabit
the gut. To colonize our bodies, these microbes have evolved strategies to regulate the …

Small molecule immunomodulins from cultures of the human microbiome member Lactobacillus plantarum

R Zvanych, N Lukenda, JJ Kim, X Li, EO Petrof… - The Journal of …, 2014 - nature.com
Lactobacillus plantarum strains are noted for their presence in the human gastrointestinal
tract and are distinguished for their immunomodulatory actions and therapeutic applications …

Lactosmart: a novel therapeutic molecule for antimicrobial defense

J Singh, V Vijayan, S Ahmedi, P Pant… - Frontiers in …, 2021 - frontiersin.org
The problem of antibiotic resistance has prompted researchers around the globe to search
for new antimicrobial agents. Antimicrobial proteins and peptides are naturally secreted by …

Design and development of a novel peptide for treating intestinal inflammation

L Zhang, X Wei, R Zhang, JN Petitte, D Si, Z Li… - Frontiers in …, 2019 - frontiersin.org
Intestinal inflammatory disorders, such as inflammatory bowel disease (IBD), are associated
with increased pro-inflammatory cytokine secretion in the intestines. Furthermore, intestinal …

Antimicrobial peptides could antagonize uncontrolled inflammation via Toll-like 4 receptor

DF Buccini, BC Roriz, JM Rodrigues… - … in Bioengineering and …, 2022 - frontiersin.org
Antimicrobial peptides are part of the organism's defense system. They are multifunctional
molecules capable of modulating the host's immune system and recognizing molecules …

Phenol‐soluble‐modulin‐inspired amphipathic peptides have bactericidal activity against multidrug‐resistant bacteria

P Zeng, C Xu, Q Cheng, J Liu, W Gao, X Yang… - …, 2019 - Wiley Online Library
Phenol‐soluble modulins (PSMs) are a large family of cytolytic peptide toxins produced by
Staphylococcus aureus. Based on their amino acid sequences, we have constructed a small …

The efficacy of anti‐proteolytic peptide R7I in intestinal inflammation, function, microbiota, and metabolites by multi‐omics analysis in murine bacterial enteritis

T Sun, X Liu, Y Su, Z Wang, B Cheng… - Bioengineering & …, 2023 - Wiley Online Library
Increased antibiotic resistance poses a major limitation in tackling inflammatory bowel
disease and presents a large challenge for global health care. Antimicrobial peptides …

In silico and in vitro analyses reveal promising antimicrobial peptides from myxobacteria

BS Arakal, DE Whitworth, PE James… - Probiotics and …, 2023 - Springer
Antimicrobial resistance (AMR) is a global concern, and as soon as new antibiotics are
introduced, resistance to those agents emerges. Therefore, there is an increased appetite for …

Identification of a novel antimicrobial peptide from amphioxus Branchiostoma japonicum by in silico and functional analyses

H Liu, M Lei, X Du, P Cui, S Zhang - Scientific Reports, 2015 - nature.com
The emergence of multi-drug resistant (MDR) microbes leads to urgent demands for novel
antibiotics exploration. We demonstrated a cDNA from amphioxus Branchiostoma …

Identification, Recombinant Expression, and Characterization of LGH2, a Novel Antimicrobial Peptide of Lactobacillus casei HZ1

J He, X Luo, D Jin, Y Wang, T Zhang - Molecules, 2018 - mdpi.com
L. casei HZ1 was identified from Chinese traditional fermented milk, and angiotensin
converting enzyme inhibitory peptide was separated from its culture in our previous work …