Targeted therapies in cholangiocarcinoma: emerging evidence from clinical trials

MM Simile, P Bagella, G Vidili, A Spanu, R Manetti… - Medicina, 2019 - mdpi.com
Cholangiocarcinoma (CCA) is a highly-aggressive malignancy arising from the biliary tree,
characterized by a steady increase in incidence globally and a high mortality rate. Most …

Targeted therapies in advanced cholangiocarcinoma

MH Storandt, PC Kurniali, A Mahipal, Z Jin - Life, 2023 - mdpi.com
Primary tumor resection and liver transplantation are the only curative treatment options for
the management of cholangiocarcinoma (CCA). However, for patients with advanced or …

Future directions in the treatment of cholangiocarcinoma

AX Zhu - Best practice & research Clinical gastroenterology, 2015 - Elsevier
Cholangiocarcinoma (CCA) comprises a heterogeneous group of cancers with pathologic
features of biliary tract differentiation, and is best classified anatomically as intrahepatic CCA …

[HTML][HTML] The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets

DQ Chong, AX Zhu - Oncotarget, 2016 - ncbi.nlm.nih.gov
Cholangiocarcinoma (CCA) is a relatively rare malignancy that arises from the epithelial
cells of the intrahepatic, perihilar and distal biliary tree. Intrahepatic CCA (ICC) represents …

Novel targeted treatment options for advanced cholangiocarcinoma

A Mahipal, A Kommalapati, SH Tella… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Surgical resection remains the mainstay of potentially curative treatment in the
early stages of cholangiocarcinoma, whereas for the advanced stage, systemic …

[HTML][HTML] Emerging molecular targets and therapy for cholangiocarcinoma

H Kayhanian, EC Smyth, C Braconi - World journal of …, 2017 - ncbi.nlm.nih.gov
Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor
prognosis and limited therapeutic options. Recent large scale molecular characterisation …

Systemic therapy of cholangiocarcinoma: from chemotherapy to targeted therapies

N Schweitzer, A Vogel - Best Practice & Research Clinical Gastroenterology, 2015 - Elsevier
Cholangiocarcinomas (CCA) are rare tumors of the liver with poor prognosis. The standard
of care in patients with unresectable tumors or metastatic disease is combination …

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

JM Banales, JJG Marin, A Lamarca… - Nature reviews …, 2020 - nature.com
Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …

Cholangiocarcinoma: what are the options in all comers and how has the advent of molecular profiling opened the way to personalised medicine?

GS Roth, C Neuzillet, M Sarabi, J Edeline… - European Journal of …, 2023 - Elsevier
Cholangiocarcinoma is a deadly cancer comprising very heterogenous subtypes with a
limited therapeutic arsenal in all comers. However, recent significant advances were made …

Cholangiocarcinoma: new perspectives for new horizons

M Rimini, M Puzzoni, F Pedica, N Silvestris… - Expert Review of …, 2021 - Taylor & Francis
Introduction Biliary tract cancer represents a heterogeneous group of malignancies
characterized by dismal prognosis and scarce therapeutic options. Area covered In the last …