Fine-tuning the gut ecosystem: the current landscape and outlook of artificial microbiome therapeutics

S Porcari, W Fusco, I Spivak, M Fiorani… - The Lancet …, 2024 - thelancet.com
The gut microbiome is acknowledged as a key determinant of human health, and
technological progress in the past two decades has enabled the deciphering of its …

Current Regulation and Initial Considerations for Successful Development and Commercialization of Microbiome Therapies

D Thanush, HC Basavaraj… - Advanced Gut & …, 2023 - Wiley Online Library
The gut microbiome is frequently referred to as the “second brain” or “second genome,”
referring to the impact of the gut microbiota on our health. The microbiome is formed at birth …

the future of microbiome‐based therapeutics

EL Gulliver, RB Young… - Alimentary …, 2022 - Wiley Online Library
Background From consumption of fermented foods and probiotics to emerging applications
of faecal microbiota transplantation, the health benefit of manipulating the human microbiota …

Microbiome therapeutics: exploring the present scenario and challenges

M Yadav, NS Chauhan - Gastroenterology report, 2022 - academic.oup.com
Human gut-microbiome explorations have enriched our understanding of microbial
colonization, maturation, and dysbiosis in health-and-disease subsets. The enormous …

The human gut microbiome as source of innovation for health: Which physiological and therapeutic outcomes could we expect?

J Doré, MC Multon, JM Behier, H Affagard… - Therapies, 2017 - Elsevier
From the moment of birth, each human being builds a microbe-host symbiosis which is key
for the preservation of its health and well-being. This personal symbiotic coexistence is the …

Future modulation of gut microbiota: from eubiotics to FMT, engineered bacteria, and phage therapy

C Airola, A Severino, S Porcari, W Fusco, BH Mullish… - Antibiotics, 2023 - mdpi.com
The human gut is inhabited by a multitude of bacteria, yeasts, and viruses. A dynamic
balance among these microorganisms is associated with the well-being of the human being …

Microbiota-directed biotherapeutics: Considerations for quality and functional assessment

EE Fekete, D Figeys, X Zhang - Gut Microbes, 2023 - Taylor & Francis
Mounting evidence points to causative or correlative roles of gut microbiome in the
development of a myriad of diseases ranging from gastrointestinal diseases, metabolic …

Nifty new tools for microbiome treatment design

J Raes - Nature Reviews Gastroenterology & Hepatology, 2023 - nature.com
The gut microbiome field is shifting from association to modulation. Microbiota-based
treatments come in many shapes and sizes, ranging from dietary intervention to live …

New approaches to microbiome-based therapies

AC Wong, M Levy - MSystems, 2019 - Am Soc Microbiol
Over the last decade, our understanding of the composition and functions of the gut
microbiota has greatly increased. To a large extent, this has been due to the development of …

Gut microbiome-oriented therapy for metabolic diseases: challenges and opportunities towards clinical translation

X Zhang, X Cai, X Zheng - Trends in Pharmacological Sciences, 2021 - cell.com
Gut microbial changes have been causally associated with metabolic diseases, triggering
huge interest in designing gut microbiome-based therapy. Here we discuss the open …