The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

Abstract Interleukin‐1β (IL‐1β) is a prototypical multifunctional cytokine that plays an
important role in intestinal inflammation of Crohn's disease and other inflammatory …

Cytokines play a crucial role in the modulation of inflammatory response in the
gastrointestinal tract. Pro-inflammatory cytokines including tumor necrosis factor-α, interferon …

IL-1β is a proinflammatory cytokine that plays a central role in the inflammatory process of
the gut. IL-1β causes an increase in intestinal epithelial tight junction (TJ) permeability, but …

Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of
macromolecules. The TJ is multi-protein complex that forms a selective permeable seal …

Defective intestinal epithelial tight junction (TJ) barrier has been shown to be a pathogenic
factor in the development of intestinal inflammation. Interleukin-6 (IL-6) is a pleiotropic, pro …

The IL-1β-induced increase in intestinal epithelial tight junction (TJ) permeability has been
postulated to be an important mechanism contributing to intestinal inflammation of Crohn's …

IL-1β is a prototypical proinflammatory cytokine that plays a central role in the intestinal
inflammation amplification cascade. Recent studies have indicated that a TNF-α-and IFN-γ …

BACKGROUND & AIMS: Defects in the intestinal epithelial tight junction (TJ) barrier
contribute to intestinal inflammation. A tumor necrosis factor (TNF)-α–induced increase in …

The defective intestinal epithelial tight junction (TJ) barrier has been postulated to be an
important pathogenic factor contributing to intestinal inflammation. It has been shown that …