Evidence for the importance of angiotensin II type 1 receptor in ischemia-induced angiogenesis

K Sasaki, T Murohara, H Ikeda… - The Journal of …, 2002 - Am Soc Clin Investig
The role of the renin-angiotensin system (RAS) in angiogenesis is little known. Here, we
show that the angiotensin II (ATII) type 1 (AT1) receptor plays an important role in ischemia …

Angiotensin II type 1a receptor is involved in cell infiltration, cytokine production, and neovascularization in infarcted myocardium

H Toko, Y Zou, T Minamino, M Sakamoto… - … , and vascular biology, 2004 - Am Heart Assoc
Objective—Angiotensin II is critically involved in left ventricular remodeling after myocardial
infarction. Neovascularization has been thought to prevent the development of left …

Antiangiogenic effect of angiotensin II type 2 receptor in ischemia-induced angiogenesis in mice hindlimb

JS Silvestre, R Tamarat, T Senbonmatsu… - Circulation …, 2002 - Am Heart Assoc
This study examined the potential role of angiotensin type 2 (AT2) receptor on angiogenesis
in a model of surgically induced hindlimb ischemia. Ischemia was produced by femoral …

Differential regulation of in vivo angiogenesis by angiotensin II receptors

T Walther, A Menrad, HD Orzechowski… - The FASEB …, 2003 - Wiley Online Library
ABSTRACT Angiotensin II (ANG II), a key regulator of blood pressure and body fluid
homeostasis, exerts mitogenic effects on endothelial cells. We therefore hypothesized that …

Role of bradykinin, nitric oxide, and angiotensin II type 2 receptor in imidapril-induced angiogenesis

P Li, T Kondo, Y Numaguchi, K Kobayashi, M Aoki… - …, 2008 - Am Heart Assoc
The angiotensin II (Ang II)-Ang II type 1 receptor pathway is proangiogenic, whereas studies
showed that some angiotensin-converting enzyme inhibitors also stimulate angiogenesis in …

Reduced angiogenesis and delay in wound healing in angiotensin II type 1a receptor-deficient mice

M Kurosaka, T Suzuki, K Hosono, Y Kamata… - Biomedicine & …, 2009 - Elsevier
Angiotensin II (Ang II) is a bioactive peptide that plays important roles in blood pressure
regulation and salt–water homeostasis. Recently, Ang II was reported to function in the …

Angiotensin AT1 receptor signalling modulates reparative angiogenesis induced by limb ischaemia

C Emanueli, MB Salis, T Stacca, A Pinna… - British journal of …, 2002 - Wiley Online Library
The concept that angiotensin II exerts pro‐angiogenic activity is not universally accepted.
We evaluated whether inhibition of the renin‐angiotensin system (RAS) would influence …

Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension

MA Sparks, KK Parsons, J Stegbauer, SB Gurley… - …, 2011 - Am Heart Assoc
Vascular injury and remodeling are common pathological sequelae of hypertension.
Previous studies have suggested that the renin-angiotensin system acting through the type 1 …

Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation …

L Wu, M Iwai, H Nakagami, Z Li, R Chen, J Suzuki… - Circulation, 2001 - Am Heart Assoc
Background To investigate the effect of angiotensin (Ang) II type 1 receptor (AT1) blocker on
vascular remodeling and explore the possibility of the involvement of Ang II type 2 receptor …

Angiotensin II type 1A receptor expressed in smooth muscle cells is required for hypertensive vascular remodeling in mice infused with angiotensin II

K Okuno, K Torimoto, SM Cicalese, K Preston… - …, 2023 - Am Heart Assoc
Background: Ang II (angiotensin II) type 1 (AT1) receptors play a critical role in
cardiovascular diseases such as hypertension. Rodents have 2 types of AT1 receptor (AT1A …