The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

The prevalence of carbapenem-resistant gram-negative bacterial pathogens (CRGNs) has
increased dramatically during the last 10 years, but the optimal treatment for CRGN …

We assessed the prevalence of polymyxin B (PMB)-and tigecycline (TGC)-heteroresistant
Klebsiella pneumoniae isolates and investigated the combined effect of PMB and TGC …

The emergence of resistant to carbapenems Gram-negative bacteria (CR GNB) has severely
challenged antimicrobial therapy. Many CR GNB isolates are only susceptible to …

Introduction The emergence of carbapenemase resistant Gram-negative is designated as an
'urgent'priority of public health. Carbapenemase producing Klebsiella pneumoniae (CPKP) …

Background Healthcare-associated infections caused by Klebsiella pneumoniae isolates
are increasing and few effective antibiotics are currently available to treat patients. We …

ABSTRACT Introduction: Multi-drug-resistant Klebsiella pneumoniae is currently one of the
most pressing emerging issues in bacterial resistance. Treatment of K. pneumoniae …

Background Rates of colonization and infection with carbapenem-resistant Gram-negative
pathogens are on the rise, particularly in southeastern European countries, and this is …

Carbapenem-resistant Enterobacterales, such as Klebsiella pneumoniae carbapenemase
(KPC)-producing K. pneumoniae, represent a major threat to public health due to their rapid …

Carbapenems are considered as last-resort antibiotics for the treatment of infections caused
by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in …