Worldwide, 80% of patients who undergo surgery receive opioid analgesics as the
fundamental agent for pain relief. However, the irrational use of opioids leads to excessive …

Objectives. Patients taking opioids prior to surgery experience prolonged postoperative
opioid use, worse clinical outcomes, increased pain, and more postoperative complications …

Abstract Objectives The United States is experiencing an opioid overdose crisis. Research
suggests prolonged postoperative opioid use, a common complication following surgery, is …

BACKGROUND: Determinants of the duration of opioid use after surgery have not been
reported. We hypothesized that both preoperative psychological distress and substance …

Physicians, policymakers, and researchers are increasingly focused on finding ways to
decrease opioid use and overdose in the United States both of which have sharply …

Abstract Purpose of Review This review aims to summarize interventions used in the
perioperative period to reduce the development of new persistent postoperative opioid use …

Importance Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis
that started in North America and spread throughout high-income countries. The aim of this …

Importance Opioids administered to treat postsurgical pain are a major contributor to the
opioid crisis, leading to chronic use in a considerable proportion of patients. Initiatives …

Background There are a number of studies in the literature that describe the prevalence,
causes, and factors associated with chronic postoperative opioid use, but there is a lack of …

In the midst of an epidemic of opioid abuse and overdose-related morbidity and mortality,
the use of opioids remains the most common means of providing analgesia in the …