Novel TLR7 hemizygous variant in post-COVID-19 neurological deterioration: a case report with literature review

A Noor Eddin, M Al-Rimawi, F Peer-Zada… - Frontiers in …, 2023 - frontiersin.org
The neurological complications of coronavirus disease 2019 (COVID-19) can range from
simple tremors and dystonia to features of encephalopathy. Toll-like receptor 7 (TLR7) …

[HTML][HTML] Novel TLR7 hemizygous variant in post-COVID-19 neurological deterioration: a case report with literature review

AN Eddin, M Al-Rimawi, F Peer-Zada… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
The neurological complications of coronavirus disease 2019 (COVID-19) can range from
simple tremors and dystonia to features of encephalopathy. Toll-like receptor 7 (TLR7) …

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome inmice

FLF Dantas, GG Fernandes, EG Gutman, EVD Lima… - 2023 - arca.fiocruz.br
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2

D Kaushik, R Bhandari, A Kuhad - Expert Opinion on Therapeutic …, 2021 - Taylor & Francis
Introduction: The COVID-19 pandemic remains aglobal challenge. While there are mRNA
agents on the horizon as apotential prevention, adefinitive drug therapy is an unmet medical …

FROM SEVERE COVID-19 INFECTION TO GENETIC REVELATION: TOLL-LIKE RECEPTOR 7 DEFICIENCY IN TWO BROTHERS

B Schornack, M Leondaridis, J McMurray… - Annals of Allergy …, 2023 - Elsevier
Introduction Toll-like receptor 7 (TLR7) plays an important role in the innate immune
response against SARS-CoV-2. Described in this report are two brothers who initially …

COVID-19 (novel SARS-CoV-2) neurological illness

DS Younger - Handbook of Clinical Neurology, 2023 - Elsevier
COVID-19 illness is associated with diverse neurological manifestations. Its exceptionally
high prevalence results from unprecedented genetic diversity, genomic recombination, and …

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

X Solanich, G Vargas-Parra, CI Van der Made… - Frontiers in …, 2021 - frontiersin.org
Introduction Loss-of-function TLR7 variants have been recently reported in a small number
of males to underlie strong predisposition to severe COVID-19. We aimed to determine the …

X-linked TLR7 deficiency underlies critical COVID-19 pneumonia in a male patient with ataxia-telangiectasia

H Abolhassani, A Vosughimotlagh, T Asano… - Journal of clinical …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of
clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the …

Mild COVID-19 infection in an NMO patient treated with tocilizumab: a confirmation of anti-IL-6 protective role?

V Mantero, A Rigamonti, P Basilico, M Crespi… - Journal of …, 2020 - Springer
The novel coronavirus SARS-CoV-2 (which results in COVID-19) was recently discovered in
Wuhan, China. Its morbidity and mortality have been associated with acute respiratory …