[HTML][HTML] Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants

A Mittal, A Khattri, V Verma - PLoS Pathogens, 2022 - journals.plos.org
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus is continuously
evolving, and this poses a major threat to antibody therapies and currently authorized …

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

J Dong, SJ Zost, AJ Greaney, TN Starr, AS Dingens… - BioRxiv, 2021 - biorxiv.org
The SARS-CoV-2 pandemic has led to an urgent need to understand the molecular basis for
immune recognition of SARS-CoV-2 spike (S) glycoprotein antigenic sites. To define the …

[HTML][HTML] SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

D Mannar, JW Saville, Z Sun, X Zhu, MM Marti… - Nature …, 2022 - nature.com
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently
been shown to enhance aspects of spike protein fitness. Here, we describe an antibody …

[HTML][HTML] SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms

SA Clark, LE Clark, J Pan, A Coscia, LGA McKay… - Cell, 2021 - cell.com
Many individuals mount nearly identical antibody responses to SARS-CoV-2. To gain insight
into how the viral spike (S) protein receptor-binding domain (RBD) might evolve in response …

[HTML][HTML] Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies

M Alenquer, F Ferreira, D Lousa, M Valério… - PLoS …, 2021 - journals.plos.org
Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19
pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin …

[HTML][HTML] Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

D Van Egeren, A Novokhodko, M Stoddard, U Tran… - PloS one, 2021 - journals.plos.org
The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for
many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under …

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

L Zhang, L Cao, XS Gao, BY Zheng… - National Science …, 2021 - academic.oup.com
Mutations and transient conformational movements of the receptor binding domain (RBD)
that make neutralizing epitopes momentarily unavailable present immune escape routes for …

SARS-CoV-2 spike S2-specific neutralizing antibodies

CJ Li, SC Chang - Emerging Microbes & Infections, 2023 - Taylor & Francis
Since the onset of the coronavirus disease 2019 (COVID-19), numerous neutralizing
antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity

HM Mengist, AJK Kombe, D Mekonnen, A Abebaw… - Seminars in …, 2021 - Elsevier
Responsible for more than 4.9 million deaths so far, COVID-19, caused by SARS-CoV-2, is
instigating devastating effects on the global health care system whose impacts could be …

[HTML][HTML] A structural landscape of neutralizing antibodies against SARS-CoV-2 receptor binding domain

L Niu, KN Wittrock, GC Clabaugh, V Srivastava… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has
been spreading rampantly. The global scientific community has responded rapidly to …