Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury,
coronary circulation is a so far neglected target of cardioprotection. In this study, we …

Endothelial cells lining the microvasculature are particularly vulnerable to the deleterious
effects of cardiac ischemia/reperfusion (I/R) injury, a susceptibility that is partially mediated …

Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal
transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH) …

Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Aims The FDA-approved histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic
acid (SAHA, Vorinostat) has been shown to induce cardiomyocyte autophagy and blunt …

Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Rationale: Cardiovascular diseases, such as myocardial infarction (MI), are the leading
causes of death worldwide. Reperfusion therapy is the common standard treatment for MI …

Microvascular damage is a key pathological change in myocardial ischemia/reperfusion
(I/R) injury. Using a rat model of myocardial I/R, our current study has provided the first …

We have previously shown that mitochondria-targeted vitamin E (Mito-Vit-E), a mtROS
specific antioxidant, improves cardiac performance and attenuates inflammation in a …