Cholinesterase inhibitors as Alzheimer's therapeutics

K Sharma - Molecular medicine reports, 2019 - spandidos-publications.com
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic
syndrome of the central nervous system that causes a decline in cognitive function and …

Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease

A Martinez, A Castro - Expert opinion on investigational drugs, 2006 - Taylor & Francis
Current pharmacotherapy for Alzheimer's disease involves compounds that are aimed at
increasing the levels of acetylcholine in the brain by facilitating cholinergic …

Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment

A Musial, M Bajda, B Malawska - Current medicinal chemistry, 2007 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …

Cholinesterase inhibitors for Alzheimer's disease: multitargeting strategy based on anti-Alzheimer's drugs repositioning

MT Kabir, MS Uddin, M Begum… - Current …, 2019 - ingentaconnect.com
In the brain, acetylcholine (ACh) is regarded as one of the major neurotransmitters. During
the advancement of Alzheimer's disease (AD) cholinergic deficits occur and this can lead to …

Reconsideration of anticholinesterase therapeutic strategies against Alzheimer's disease

H Wang, H Zhang - ACS chemical neuroscience, 2018 - ACS Publications
Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …

Cholinesterase inhibitors for the treatment of Alzheimer's disease:: getting on and staying on

GT Grossberg - Current Therapeutic Research, 2003 - Elsevier
Background: Cholinesterase (ChE) inhibitors currently used in the treatment of Alzheimer's
disease (AD) are the acetylcholinesterase (AChE)-selective inhibitors, donepezil and …

Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents

DK Lahiri, JT Rogers, NH Greig… - Current …, 2004 - ingentaconnect.com
Alzheimer's disease (AD) is characterized by progressive dementia caused by the loss of the
presynaptic markers of the cholinergic system in the brain areas related to memory and …

New Acetylcholinesterase Inhibitors for Alzheimer′ s Disease

M Mehta, A Adem, M Sabbagh - International Journal of …, 2012 - Wiley Online Library
Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic
improvement in Alzheimer′ s disease (AD) because cholinergic deficit is a consistent and …

Cholinesterase inhibitors for Alzheimer's disease

J Grutzendler, JC Morris - Drugs, 2001 - Springer
Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and
has become an urgent public health problem in most areas of the world. Substantial …

Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update

MR Loizzo, R Tundis, F Menichini… - Current Medicinal …, 2008 - ingentaconnect.com
Alzheimer's disease (AD) is the most common form of neurodegenerative disorders. If more
effective therapies than the ones currently available are not developed that either prevent …