Rotavirus NSP4 is a viral enterotoxin capable of causing diarrhea in neonatal mice. This
process is initiated by the binding of extracellular NSP4 to target molecule (s) on the cell …

Rotavirus is the most important cause of viral gastroenteritis and dehydrating diarrhea in
young children. Rotavirus nonstructural protein 4 (NSP4) is an enterotoxin that was …

The rotavirus NSP4 protein is cytotoxic when transiently expressed in cells and is capable of
inducing secretory diarrhea in neonatal mice. NSP4 consists of 175 amino acids, and …

The rotavirus enterotoxin, NSP4, is a novel secretory agonist that also plays a role in the
unique rotavirus morphogenesis that involves a transient budding of newly made immature …

Group A rotaviruses are major intestinal pathogens that express potential α 4 β 1 and α 4 β 7
integrin ligand sequences Leu–Asp–Val and Leu–Asp–Ile in their outer capsid protein VP7 …

Previous studies have shown that the nonstructural glycoprotein NSP4 plays a role in
rotavirus pathogenesis by functioning as an enterotoxin. One prediction of the mechanism of …

Rotavirus NSP4 is a multifunctional endoplasmic reticulum (ER)-resident nonstructural
protein with the N terminus anchored in the ER and about 131 amino acids (aa) of the C …

Publisher Summary The clinical significance of rotavirus (RV)-induced diarrheal disease that
causes high morbidity in children in developed countries and high mortality in children in …

The rotavirus nonstructural NSP4 protein, a transmembrane endoplasmic reticulum-specific
glycoprotein, has been described as the first viral enterotoxin. Purified NSP4 or a peptide …

Comparison of the NSP4 amino acid sequences from 31 strains of mammalian rotaviruses
revealed the presence of four distinct NSP4 alleles; ie, the Wa, KUN, AU-1, and EW alleles …