Multiple instances of ancient balancing selection shared between humans and chimpanzees

EM Leffler, Z Gao, S Pfeifer, L Ségurel, A Auton… - Science, 2013 - science.org
Instances in which natural selection maintains genetic variation in a population over millions
of years are thought to be extremely rare. We conducted a genome-wide scan for long-lived …

Natural selection interacts with recombination to shape the evolution of hybrid genomes

M Schumer, C Xu, DL Powell, A Durvasula, L Skov… - Science, 2018 - science.org
To investigate the consequences of hybridization between species, we studied three
replicate hybrid populations that formed naturally between two swordtail fish species …

Selection against admixture and gene regulatory divergence in a long-term primate field study

TP Vilgalys, AS Fogel, JA Anderson, RS Mututua… - Science, 2022 - science.org
Genetic admixture is central to primate evolution. We combined 50 years of field
observations of immigration and group demography with genomic data from~ 9 generations …

A limited role for balancing selection

S Asthana, S Schmidt, S Sunyaev - Trends in Genetics, 2005 - cell.com
Balancing selection has been shown to act on several genes in short-term evolutionary
contexts, but it is not known whether this force is responsible for maintaining a significant …

Haplotype variation and linkage disequilibrium in 313 human genes

JC Stephens, JA Schneider, DA Tanguay, J Choi… - Science, 2001 - science.org
Variation within genes has important implications for all biological traits. We identified 3899
single nucleotide polymorphisms (SNPs) that were present within 313 genes from 82 …

Strong male bias drives germline mutation in chimpanzees

O Venn, I Turner, I Mathieson, N de Groot, R Bontrop… - Science, 2014 - science.org
Germline mutation determines rates of molecular evolution, genetic diversity, and fitness
load. In humans, the average point mutation rate is 1.2× 10− 8 per base pair per generation …

Insights into human genetic variation and population history from 929 diverse genomes

A Bergström, SA McCarthy, R Hui, MA Almarri, Q Ayub… - Science, 2020 - science.org
INTRODUCTION Large-scale human genome-sequencing studies to date have been limited
to large, metropolitan populations or to small numbers of genomes from each group. Much …

Long-Term Balancing Selection in LAD1 Maintains a Missense Trans-Species Polymorphism in Humans, Chimpanzees, and Bonobos

JC Teixeira, C De Filippo, A Weihmann… - Molecular biology …, 2015 - academic.oup.com
Balancing selection maintains advantageous genetic and phenotypic diversity in
populations. When selection acts for long evolutionary periods selected polymorphisms may …

No need to isolate genetics

ME Soulé, LS Mills - Science, 1998 - science.org
By the age of 16 every kid knows about the cultural taboos of incest—and that it is
genetically contraindicated to marry your cousin, let alone a sibling. Avoidance of inbreeding …

Promiscuity and the primate immune system

CL Nunn, JL Gittleman, J Antonovics - Science, 2000 - science.org
The behavioral and ecological factors involved in immune system evolution remain poorly
explored. We present a phylogenetic analysis of white blood cell counts in primates to test …