demetrios.braddock@yale.edu Page 1 Supplemental Methods, Figures, and Figure Legends
for: A dual-acting DNASE1 biologic prevents autoimmunity and death in genetic and …

Systemic lupus erythematosus (SLE) is an autoimmune disease that has high morbidity and
can result in multi‐organ damage. SLE is characterized by dysregulated activation of T‐and …

A defining feature of systemic lupus erythematosus (SLE) is loss of tolerance to self-DNA,
and DNASE1L3 deficiency, the main enzyme responsible for chromatin degradation in …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that affects over
one million people in the United States. SLE is characterized by the presence of anti-nuclear …

Systemic lupus erythematosus (SLE) is an autoimmune disease caused by environmental
factors and loss of key proteins, including the endonuclease Dnase1L3. Dnase1L3 absence …

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown aetiology with a
complex genetic basis that includes many susceptibility genes on multiple chromosomes. As …

Abstract Systemic Lupus Erythematosus (SLE) is a challenging autoimmune disease with
limited treatment options. It arises from a combination of environmental factors and …

Deoxyribonuclease-γ (DNASE1L3) could be developed for therapeutic purposes in systemic
lupus erythematosus (SLE), a new study suggests.“We identified microparticle-associated …

Loss of deoxyribonuclease I (Dnase1) function is associated with systemic lupus
erythematosus (SLE) in humans and mice; however, no coding mutations in Dnase1 are …

Abstract Objective Caspase‐activated DNase (CAD) is an endonuclease that is activated by
active caspase 3 during apoptosis and is responsible for degradation of chromatin into …