Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

Blood cells participate in vital physiological processes, and their numbers are tightly
regulated so that homeostasis is maintained. Disruption of key regulatory mechanisms …

White blood cell (WBC) count is a common clinical measure from complete blood count
assays, and it varies widely among healthy individuals. Total WBC count and its constituent …

Red blood cell, white blood cell, and platelet measures, including their count, sub-type and
volume, are important diagnostic and prognostic clinical parameters for several human …

Genome-wide association studies (GWAS) have successfully identified thousands of
associations between common genetic variants and human disease phenotypes, but the …

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …

The number and volume of cells in the blood affect a wide range of disorders including
cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here …

Measurements of erythrocytes within the blood are important clinical traits and can indicate
various hematological disorders. We report here genome-wide association studies (GWAS) …

Summary Whole-genome sequencing (WGS), a powerful tool for detecting novel coding and
non-coding disease-causing variants, has largely been applied to clinical diagnosis of …