Background. While inflammation predicts mortality in treated human immunodeficiency virus
(HIV) infection, the prognostic significance of gut barrier dysfunction and phenotypic T-cell …

Objective: Microbial translocation and innate immune action characterize HIV infection.
Continued gut mucosal dysfunction during treatment and its relationship to CD4+ T-cell …

BACKGROUND & AIMS: A barrier defect of the intestinal mucosa is thought to affect the
progression of human immunodeficiency virus (HIV) infection. It is not clear whether the …

Gut-associated lymphoid tissue (GALT) is an early target for human immunodeficiency virus
type 1 (HIV-1) infection and is a site for severe CD4+ T-cell depletion. HIV-associated …

Distinct pathological events occur within the gastrointestinal (GI) tract of Asian macaques
with progressive simian immunodeficiency virus (SIV) infection and humans with human …

Gut-associated lymphoid tissue (GALT) is an important site for early HIV replication and
severe CD4+ T-cell depletion. Initiation of highly active antiretroviral therapy leads to …

The gastrointestinal mucosa is critical for maintaining the integrity and functions of the gut.
Disruption of this barrier is a hallmark and a risk factor for many intestinal and chronic …

Recent findings indicate that the majority of all CD4+ T lymphocytes are lost during acute
HIV infection, with mucosal compartments being most severely affected. The frequency of …

Objective: HIV-infected individuals with incomplete CD4+ T-cell recovery upon combination
antiretroviral therapy (cART) display high levels of immune activation and microbial …

There has recently been a resurgence of interest in the gastrointestinal pathology observed
in patients infected with HIV. The gastrointestinal tract is a major site of HIV replication …