Why brain functions may deteriorate with aging: a thermodynamic evaluation

C Yildiz, M Özilgen - International Journal of Exergy, 2022 - inderscienceonline.com
Oxidative Gibbs free energy utilisation capacity and the entropy generation rate of the brain
decreases with ageing. At the present level of our knowledge, we may say that the ageing …

Assessment of the work efficiency with exergy method in ageing muscles and healthy and enlarged hearts

J Çatak, M Özilgen, AB Olcay… - International Journal of …, 2018 - inderscienceonline.com
Thermodynamic aspects of skeletal and cardiac muscle work performance are assessed
with the data obtained from the literature. Since the second law muscle work efficiency …

Biological aging and life span based on entropy stress via organ and mitochondrial metabolic loading

K Annamalai, A Nanda - Entropy, 2017 - mdpi.com
The energy for sustaining life is released through the oxidation of glucose, fats, and proteins.
A part of the energy released within each cell is stored as chemical energy of Adenosine Tri …

Decreasing Intracellular Entropy by Increasing Mitochondrial Efficiency and Reducing ROS Formation—The Effect on the Ageing Process and Age-Related Damage

B Poljšak, I Milisav - International Journal of Molecular Sciences, 2024 - mdpi.com
A hypothesis is presented to explain how the ageing process might be influenced by
optimizing mitochondrial efficiency to reduce intracellular entropy. Research-based …

Bioenergetics of the aging heart and skeletal muscles: modern concepts and controversies

K Tepp, N Timohhina, M Puurand, A Klepinin… - Ageing research …, 2016 - Elsevier
Age-related alterations in the bioenergetics of the heart and oxidative skeletal muscle
tissues are of crucial influence on their performance. Until now the prevailing concept of …

Unsteady exergy destruction of the neuron under dynamic stress conditions

S Genc, E Sorguven, M Ozilgen, IA Kurnaz - Energy, 2013 - Elsevier
Just like all physical systems, biological systems also obey laws of thermodynamics, and as
such the useful work potential of a biological system is its exergy. In some studies, exergy of …

Interplay between bioenergetics and oxidative stress at normal brain aging. Aging as a result of increasing disbalance in the system oxidative stress–energy provision

VI Lushchak - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
At normal aging, the brain exhibits signs of compromised bioenergetic and increased levels
of products of interaction between reactive oxygen/nitrogen species (ROS/RNS) and brain …

[PDF][PDF] Effect of aging on the second law efficiency, exergy destruction and entropy generation in the skeletal muscles during exercise

J Çatak, B Yılmaz, M Ozilgen - International Journal of Biomedical …, 2017 - researchgate.net
The second law muscle work efficiency is obtained by multiplying the metabolic and
mechanical work efficiencies. Thermodynamic analyses are carried out with 19 sets of arms …

In vivo and in vitro assessment of brain bioenergetics in aging rats

O Vančová, L Bačiak, S Kašparová… - Journal of cellular …, 2010 - Wiley Online Library
Brain energy disorders can be present in aged men and animals. To this respect, the
mitochondrial and free radical theory of aging postulates that age‐associated brain energy …

Effect of aging on brain energy-metabolism

N Zarchin, S Meilin, J Rifkind, A Mayevsky - Comparative Biochemistry and …, 2002 - Elsevier
The aging process involves morphological and functional changes in cerebral vasculature
and deterioration of mitochondrial number and function. Furthermore, slow oscillations of …