[HTML][HTML] Antigenic evolution of SARS coronavirus 2

AZ Mykytyn, RAM Fouchier, BL Haagmans - Current Opinion in Virology, 2023 - Elsevier
SARS coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, emerged in China in
December 2019. Vaccines developed were very effective initially, however, the virus has …

Vaccination with Span, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice

Y Zhao, W Ni, S Liang, L Dong, M Xiang, Z Cai… - Science Translational …, 2023 - science.org
SARS-CoV-2 continues to accumulate mutations to evade immunity, leading to
breakthrough infections after vaccination. How researchers can anticipate the evolutionary …

SARS-CoV-2 variants, vaccines, and host immunity

P Mistry, F Barmania, J Mellet, K Peta… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus
that emerged at the end of 2019 in the Hubei province of China. SARS-CoV-2 causes …

[HTML][HTML] SARS-CoV-2 variants–evolution, spike protein, and vaccines

KWK Chen, DTN Huang, LM Huang - biomedical journal, 2022 - Elsevier
Abstracts Despite the rising natural and vaccines mediated immunity, several countries have
experienced a resurgence of the Coronavirus disease of 2019 (COVID-19) due to the …

[HTML][HTML] The effect of spike mutations on SARS-CoV-2 neutralization

C Rees-Spear, L Muir, SA Griffith, J Heaney, Y Aldon… - Cell reports, 2021 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show
protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the …

Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development

X He, C He, W Hong, J Yang… - Medicinal Research …, 2023 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic can hardly end with the
emergence of different variants over time. In the past 2 years, several variants of severe …

Challenges and developments in universal vaccine design against SARS-CoV-2 variants

F Zhao, X Zai, Z Zhang, J Xu, W Chen - npj Vaccines, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had
become a global concern because of its unexpectedly high pathogenicity and …

Antigenic cartography of SARS-CoV-2 reveals that Omicron BA. 1 and BA. 2 are antigenically distinct

AZ Mykytyn, M Rissmann, A Kok, ME Rosu… - Science …, 2022 - science.org
The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy
substantially. The Omicron variant termed BA. 2, which differs substantially from BA. 1 based …

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

EC Thomson, LE Rosen, JG Shepherd, R Spreafico… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …

SARS-CoV-2 variants: A double-edged sword?

MP Jogalekar, A Veerabathini… - … Biology and Medicine, 2021 - journals.sagepub.com
Since the worldwide emergence of the COVID-19 outbreak, there have been international
concerns about the possible viral evolution into variants with underlying mutations that may …