Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

Highlights•Arf GTPases recognize effectors that are structurally unrelated to each other.•Arf-
GTP assembles effectors into multivalent membrane-binding platforms.•Effectors are …

ADP-ribosylation factor (Arf) GTP-binding proteins are among the best-characterized
members of the Ras superfamily of GTPases, with well-established functions in membrane …

Arfs are a family of Ras-related GTP-binding proteins that function in the regulation of
membrane trafficking and structure. The six mammalian Arf proteins are expressed …

At the FASEB summer research conference on “Arf Family GTPases”, held in Il Ciocco, Italy
in June, 2007, it became evident to researchers that our understanding of the family of Arf …

ADP-ribosylation factors (ARFs) 1 are 20-kDa guanine nucleotide-binding proteins,
members of the Ras GTPase superfamily that were initially recognized and purified because …

The small G proteins of the ARF family are key regulators of membrane dynamics. Many
functions of ARF proteins in cells are being revealed by studies of their regulators and …

Ras-related GTPases are positively regulated by guanine nucleotide exchange factors
(GEFs) that promote the exchange of GDP for GTP. The crystal structure of the Sec7 domain …

Membrane trafficking and remodeling of the actin cytoskeleton are critical activities
contributing to cellular events that include cell growth, migration and tumor invasion. ADP …

Database mining and phylogenetic analysis of the Arf (ADP-ribosylation factor) superfamily
revealed the presence in mammals of at least 22 members, including the six Arfs, two Sars …