Centenarians without dementia can be considered as a model of successful ageing and
resistance against age-related cognitive decline. Is there something special about their brain …

Aging is associated with changes in brain functional patterns as well as cognition. The
present research sought to investigate longitudinal changes in whole brain functional …

Age-related changes in the brain connectivity of healthy older adults have been widely
studied in recent years, with some differences in the obtained results. Most of these studies …

Background: Vast increases in life expectancy over the last century have led to shifts in
population demographics and the emergence of a largely aged population, globally. This …

The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of
aging. The disconnection between them is suggested to be an important cause of cognitive …

Increasing evidence suggests that functional brain connectivity is an important determinant
of cognitive aging. However, the fundamental concept of inter-individual variations in …

Background Intervention against age-related neurodegenerative diseases may be difficult
once extensive structural and functional deteriorations have already occurred in the brain …

Normal aging is known to be accompanied by decreased segregation across the whole-
brain functional network, which is associated with cognitive decline. Although compelling …

Aging leads to global changes in brain structure and cognitive performance, with
reorganization of functional brain networks. Importantly, these age-related changes show …

Aims Population aging is burdening the society globally, and the evaluation of functional
networks is the key toward understanding cognitive changes in normal aging. However, the …