Elucidating how the environment affects human health will further our understanding of
disease risk and prevention, and our potential for adaptation, such as how metabolism …

Elucidating how the environment affects human health will further our understanding of
disease risk and prevention, and adaptation. Recent evidence reveals that exposure to …

Both human and animal studies indicate that environmental exposures experienced during
early life can robustly influence risk for adult disease. Moreover, environmental exposures …

Highlights•Epigenetic information can be altered by environmental stressors.•The
mechanisms of epigenetic inheritance are complex and unclear.•DNA and histone …

Traditionally, we understand that individual phenotypes result primarily from inherited
genetic variants together with environmental exposures. However, many studies showed …

There is a growing body of evidence suggesting that parental environmental conditions can
influence the health and longevity of future generations. Recent advances provide crucial …

Organisms have evolved the processes of developmental plasticity to adjust their
developmental trajectory in response to early life exposure to environmental cues. The …

Severe or chronic stress and trauma can have a detrimental impact on health. Evidence
suggests that early-life adversity can become biologically embedded and has the potential …

Environmental exposures can have profound consequences for health and development,
and epigenetic modifications have been proposed as a mechanism for these effects. In …

Transgenerational epigenetic inheritance has gained increased attention due to the
possibility that exposure to environmental contaminants induce diseases that propagate …