Chromosome segregation errors in mammalian oocyte meiosis lead to developmentally
compromised aneuploid embryos and become more common with advancing maternal age …

Advanced maternal age is unequivocally associated with increased aneuploidy in human
eggs and infertility, but the molecular basis for this phenomenon is unknown. An age …

The generation of a viable, diploid organism depends on the formation of haploid gametes,
oocytes, and spermatocytes, with the correct number of chromosomes. Halving the genome …

Mammalian oocyte quality degrades over time after ovulation in vitro, which can cause fatal
defects such as chromosomal aneuploidy. As various oocyte manipulations employed in …

In mammalian oocytes DNA damage can cause chromosomal abnormalities that potentially
lead to infertility and developmental disorders. However, there is little known about the …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that monitors the
quality of the spindle during division and blocks anaphase entry in the presence of …

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte
aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and …

The spindle assembly checkpoint (SAC) prevents aneuploidy by coupling anaphase onset,
through anaphase-promoting complex (APC) activation, with chromosome attachment to …

The spindle assembly checkpoint (SAC) functions as a surveillance mechanism to detect
chromosome misalignment and to delay anaphase until the errors are corrected. The SAC is …

Meiotic defects cause abnormal chromosome segregation leading to aneuploidy in
mammalian oocytes. Chromosome segregation is particularly error‐prone in human …